Side-by-Side Comparison · 2026

Chlorotoxin vs Mastoparan

Chlorotoxin vs Mastoparan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Chlorotoxin
Venom Peptide

Chlorotoxin is a 36-residue peptide toxin from the deathstalker scorpion (Leiurus quinquestriatus). Originally identified as a chloride channel blocker, it was discovered to bind selectively and with high affinity to glioma cells but not normal brain tissue, through interaction w...

Calculate Chlorotoxin dose →
Mastoparan
Venom Peptide

Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface receptors, making it a unique pharmacological tool for dissecting G protein-coupled ...

Calculate Mastoparan dose →
Key Parameters
Parameter Chlorotoxin Mastoparan
Category Venom Peptide Venom Peptide
Research Phase 2 Preclinical/Research Tool
Half-Life Hours (disulfide stabilized) < 15 min (plasma)
Typical Dose N/A Research only
Frequency N/A N/A
Route IV (imaging agent); Topical (research) IV, local (research)
FDA Status Investigational (BLZ-100 Phase 2) No approval

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Chlorotoxin Calculate Mastoparan
Frequently Asked Questions
What is the difference between Chlorotoxin and Mastoparan?
Chlorotoxin: Chlorotoxin is a 36-residue peptide toxin from the deathstalker scorpion (Leiurus quinquestriatus). Originally identified as a chloride channel blocker, it was discovered to bind selectively and with ... Mastoparan: Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface rece...
Which has a longer half-life, Chlorotoxin or Mastoparan?
Chlorotoxin half-life: Hours (disulfide stabilized). Mastoparan half-life: < 15 min (plasma).
Can you stack Chlorotoxin and Mastoparan?
Chlorotoxin and Mastoparan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.