Side-by-Side Comparison · 2026

Chlorotoxin vs ShK

Chlorotoxin vs ShK — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Chlorotoxin
Venom Peptide

Chlorotoxin is a 36-residue peptide toxin from the deathstalker scorpion (Leiurus quinquestriatus). Originally identified as a chloride channel blocker, it was discovered to bind selectively and with high affinity to glioma cells but not normal brain tissue, through interaction w...

Calculate Chlorotoxin dose →
ShK
Venom Peptide

ShK is a 35-residue peptide toxin from the sea anemone Stichodactyla helianthus. 3 potassium channel (Kd ~11 pM), which is the dominant channel controlling membrane potential in effector memory T cells (TEM cells)....

Calculate ShK dose →
Key Parameters
Parameter Chlorotoxin ShK
Category Venom Peptide Venom Peptide
Research Phase 2 Phase 2
Half-Life Hours (disulfide stabilized) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route IV (imaging agent); Topical (research) SC injection (research)
FDA Status Investigational (BLZ-100 Phase 2) Investigational (dalazatide)

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Chlorotoxin Calculate ShK
Frequently Asked Questions
What is the difference between Chlorotoxin and ShK?
Chlorotoxin: Chlorotoxin is a 36-residue peptide toxin from the deathstalker scorpion (Leiurus quinquestriatus). Originally identified as a chloride channel blocker, it was discovered to bind selectively and with ... ShK: ShK is a 35-residue peptide toxin from the sea anemone Stichodactyla helianthus. 3 potassium channel (Kd ~11 pM), which is the dominant channel controlling membrane potential in effector memory T cell...
Which has a longer half-life, Chlorotoxin or ShK?
Chlorotoxin half-life: Hours (disulfide stabilized). ShK half-life: Hours (disulfide stabilized).
Can you stack Chlorotoxin and ShK?
Chlorotoxin and ShK are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.