Side-by-Side Comparison · 2026

CJC-1295 with DAC vs MK-677

CJC-1295 with DAC vs MK-677 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

CJC-1295 with DAC
Growth Hormone & IGF

CJC-1295 with DAC is a long-acting GHRH analog that uses a Drug Affinity Complex (DAC) technology - a reactive maleimidoproprionic acid linker that covalently bonds to plasma albumin after injection. This albumin binding dramatically extends its half-life to 6-8 days, allowing on...

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MK-677
Growth Hormone & IGF

MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advanced through Phase II trials for growth hormone deficiency, muscle wasting, and fra...

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Key Parameters
Parameter CJC-1295 with DAC MK-677
Category Growth Hormone & IGF Growth Hormone & IGF
Research Research Use Phase II (Discontinued)
Half-Life 6–8 days ~24 hours
Typical Dose 1,000–2,000 µg 10–25 mg
Frequency Once or twice weekly Once daily
Route Subcutaneous Oral
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between CJC-1295 with DAC and MK-677?
CJC-1295 with DAC: CJC-1295 with DAC is a long-acting GHRH analog that uses a Drug Affinity Complex (DAC) technology - a reactive maleimidoproprionic acid linker that covalently bonds to plasma albumin after injection. ... MK-677: MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advance...
Which has a longer half-life, CJC-1295 with DAC or MK-677?
CJC-1295 with DAC half-life: 6–8 days. MK-677 half-life: ~24 hours.
Can you stack CJC-1295 with DAC and MK-677?
CJC-1295 with DAC and MK-677 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.