Side-by-Side Comparison · 2026

Clavanin vs Pexiganan

Clavanin vs Pexiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Clavanin
Antimicrobial Peptide

Clavanin is a histidine-rich alpha-helical antimicrobial peptide originally isolated from the tunicate Styela clava. It is active at low pH, suggesting a role in intracellular killing of phagocytosed bacteria....

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Pexiganan
Antimicrobial Peptide

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later Genaera) as a topical treatment for mildly infected diabetic foot ulcers....

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Key Parameters
Parameter Clavanin Pexiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase 3 (Failed 1999)
Half-Life Short (minutes) Hours (topical)
Typical Dose N/A (research only) 0.8% cream topically
Frequency N/A Twice daily
Route Topical / IV (research) Topical cream
FDA Status Not approved Not approved (failed Phase 3)

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Frequently Asked Questions
What is the difference between Clavanin and Pexiganan?
Clavanin: Clavanin is a histidine-rich alpha-helical antimicrobial peptide originally isolated from the tunicate Styela clava. It is active at low pH, suggesting a role in intracellular killing of phagocytosed ... Pexiganan: Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later...
Which has a longer half-life, Clavanin or Pexiganan?
Clavanin half-life: Short (minutes). Pexiganan half-life: Hours (topical).
Can you stack Clavanin and Pexiganan?
Clavanin and Pexiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.