Side-by-Side Comparison · 2026

Clavanin vs Polymyxin B

Clavanin vs Polymyxin B — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Clavanin
Antimicrobial Peptide

Clavanin is a histidine-rich alpha-helical antimicrobial peptide originally isolated from the tunicate Styela clava. It is active at low pH, suggesting a role in intracellular killing of phagocytosed bacteria....

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Polymyxin B
Antimicrobial Peptide

Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in the 1960s and fell out of favor due to nephrotoxicity, but has experienced a major clinical resurgence as a last-resort treatment for carbapenem-resistant Gram-negative infections (Acinetob...

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Key Parameters
Parameter Clavanin Polymyxin B
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical FDA Approved
Half-Life Short (minutes) 6-8 hours
Typical Dose N/A (research only) 15,000-25,000 units/kg/day IV
Frequency N/A Every 12 hours IV
Route Topical / IV (research) IV / IM / Topical / Intrathecal
FDA Status Not approved Approved (systemic Gram-negative infections)

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Frequently Asked Questions
What is the difference between Clavanin and Polymyxin B?
Clavanin: Clavanin is a histidine-rich alpha-helical antimicrobial peptide originally isolated from the tunicate Styela clava. It is active at low pH, suggesting a role in intracellular killing of phagocytosed ... Polymyxin B: Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in the 1960s and fell out of favor due to nephrotoxicity, but has experienced a major clinical resurgence as a l...
Which has a longer half-life, Clavanin or Polymyxin B?
Clavanin half-life: Short (minutes). Polymyxin B half-life: 6-8 hours.
Can you stack Clavanin and Polymyxin B?
Clavanin and Polymyxin B are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.