Side-by-Side Comparison · 2026

Colistin vs Protegrin-1

Colistin vs Protegrin-1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Colistin
Antimicrobial Peptide

Colistin (polymyxin E) is a cyclic lipopeptide antibiotic structurally related to polymyxin B, differing in the fatty acid chain and one amino acid residue. Like polymyxin B, colistin targets LPS and disrupts outer membranes of Gram-negative bacteria....

Calculate Colistin dose →
Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

Calculate Protegrin-1 dose →
Key Parameters
Parameter Colistin Protegrin-1
Category Antimicrobial Peptide Antimicrobial Peptide
Research FDA Approved Phase 3 / Clinical
Half-Life Colistimethate (prodrug): 2-3 hours; active colistin: 14 hours Short
Typical Dose 2.5-5 mg/kg/day CBA IV 0.1-1 mg/mL (topical)
Frequency Every 8-12 hours BID-TID
Route IV (colistimethate) / Inhaled / Topical Topical / Oral rinse (research)
FDA Status Approved (systemic Gram-negative infections) Phase 3 clinical evaluation (iseganan)

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Colistin Calculate Protegrin-1
Frequently Asked Questions
What is the difference between Colistin and Protegrin-1?
Colistin: Colistin (polymyxin E) is a cyclic lipopeptide antibiotic structurally related to polymyxin B, differing in the fatty acid chain and one amino acid residue. Like polymyxin B, colistin targets LPS and ... Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat...
Which has a longer half-life, Colistin or Protegrin-1?
Colistin half-life: Colistimethate (prodrug): 2-3 hours; active colistin: 14 hours. Protegrin-1 half-life: Short.
Can you stack Colistin and Protegrin-1?
Colistin and Protegrin-1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.