Side-by-Side Comparison · 2026

Conotoxin vs Mastoparan

Conotoxin vs Mastoparan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Conotoxin
Venom Peptide

Conotoxins (conopeptides) are a diverse superfamily of small, disulfide-rich peptide toxins produced by predatory cone snails (Conus species). With >10,000 predicted sequences across ~700 Conus species, conotoxins are an extraordinary reservoir of pharmacologically selective tool...

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Mastoparan
Venom Peptide

Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface receptors, making it a unique pharmacological tool for dissecting G protein-coupled ...

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Key Parameters
Parameter Conotoxin Mastoparan
Category Venom Peptide Venom Peptide
Research FDA Approved (ziconotide) Preclinical/Research Tool
Half-Life Hours (intrathecal; ziconotide ~4-6 h plasma) < 15 min (plasma)
Typical Dose Ziconotide: 0.1-0.8 mcg/hr intrathecal (titrated) Research only
Frequency Continuous intrathecal infusion N/A
Route Intrathecal (ziconotide); IV (research) IV, local (research)
FDA Status Ziconotide (omega-conotoxin analog) FDA approved (Prialt) No approval

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Frequently Asked Questions
What is the difference between Conotoxin and Mastoparan?
Conotoxin: Conotoxins (conopeptides) are a diverse superfamily of small, disulfide-rich peptide toxins produced by predatory cone snails (Conus species). With >10,000 predicted sequences across ~700 Conus specie... Mastoparan: Mastoparan is a 14-amino acid amphipathic peptide from the venom of the wasp Vespula lewisii and related species. It directly activates heterotrimeric Gi/Go proteins independently of cell surface rece...
Which has a longer half-life, Conotoxin or Mastoparan?
Conotoxin half-life: Hours (intrathecal; ziconotide ~4-6 h plasma). Mastoparan half-life: < 15 min (plasma).
Can you stack Conotoxin and Mastoparan?
Conotoxin and Mastoparan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.