Side-by-Side Comparison · 2026

Cortexin vs PE-22-28

Cortexin vs PE-22-28 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortexin
Cognitive & Neurological

Cortexin is a polypeptide complex extracted from the cerebral cortex of pigs (porcine origin) that contains a mixture of low-molecular-weight neuropeptides, amino acids, and protein fractions. It is an approved drug in Russia, used clinically for stroke recovery, traumatic brain ...

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PE-22-28
Cognitive & Neurological

PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that regulates neuronal excitability. TREK-1 is strongly implicated in depression and c...

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Key Parameters
Parameter Cortexin PE-22-28
Category Cognitive & Neurological Cognitive & Neurological
Research Approved (Russia/CIS) Preclinical
Half-Life - -
Typical Dose 10 mg 100–200 µg
Frequency Once daily Daily
Route Intramuscular Subcutaneous / Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between Cortexin and PE-22-28?
Cortexin: Cortexin is a polypeptide complex extracted from the cerebral cortex of pigs (porcine origin) that contains a mixture of low-molecular-weight neuropeptides, amino acids, and protein fractions. It is a... PE-22-28: PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that re...
Which has a longer half-life, Cortexin or PE-22-28?
Cortexin half-life: unknown. PE-22-28 half-life: unknown.
Can you stack Cortexin and PE-22-28?
Cortexin and PE-22-28 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.