Side-by-Side Comparison · 2026

Cortexin vs Semax Amidate

Cortexin vs Semax Amidate — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortexin
Cognitive & Neurological

Cortexin is a polypeptide complex extracted from the cerebral cortex of pigs (porcine origin) that contains a mixture of low-molecular-weight neuropeptides, amino acids, and protein fractions. It is an approved drug in Russia, used clinically for stroke recovery, traumatic brain ...

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Semax Amidate
Cognitive & Neurological

Semax Amidate (Semax-NH2) is Semax with C-terminal amidation - the addition of an amide group (-NH2) replacing the C-terminal carboxyl group (-COOH). This modification protects against carboxypeptidase degradation in nasal tissue, extending half-life and improving CNS bioavailabi...

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Key Parameters
Parameter Cortexin Semax Amidate
Category Cognitive & Neurological Cognitive & Neurological
Research Approved (Russia/CIS) Research Use
Half-Life - ~6 hours (estimated)
Typical Dose 10 mg 100–400 µg
Frequency Once daily Once or twice daily
Route Intramuscular Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between Cortexin and Semax Amidate?
Cortexin: Cortexin is a polypeptide complex extracted from the cerebral cortex of pigs (porcine origin) that contains a mixture of low-molecular-weight neuropeptides, amino acids, and protein fractions. It is a... Semax Amidate: Semax Amidate (Semax-NH2) is Semax with C-terminal amidation - the addition of an amide group (-NH2) replacing the C-terminal carboxyl group (-COOH). This modification protects against carboxypeptidas...
Which has a longer half-life, Cortexin or Semax Amidate?
Cortexin half-life: unknown. Semax Amidate half-life: ~6 hours (estimated).
Can you stack Cortexin and Semax Amidate?
Cortexin and Semax Amidate are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.