CRH (Corticotropin-Releasing Hormone) vs TRH (Thyrotropin-Releasing Hormone) — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?
Corticotropin-releasing hormone (CRH, also called CRF) is the primary hypothalamic regulator of the stress response and HPA axis. The 41-amino acid peptide is released from the paraventricular nucleus (PVN) of the hypothalamus and acts on pituitary corticotrophs to stimulate ACTH...
Calculate CRH (Corticotropin-Releasing Hormone) dose →Thyrotropin-releasing hormone (TRH) is the smallest known hypothalamic releasing hormone, a modified tripeptide (pyroGlu-His-Pro-NH2) that stimulates TSH and prolactin release from the anterior pituitary. Despite its small size, TRH has extensive actions beyond the thyroid axis i...
Calculate TRH (Thyrotropin-Releasing Hormone) dose →| Parameter | CRH (Corticotropin-Releasing Hormone) | TRH (Thyrotropin-Releasing Hormone) |
|---|---|---|
| Category | Hypothalamic Hormone | Hypothalamic Hormone |
| Research | Preclinical/Clinical Research | FDA Approved (Diagnostic) |
| Half-Life | ~30-68 min (plasma) | ~2-5 min (plasma) |
| Typical Dose | CRH stimulation test: 1 ug/kg or 100 ug IV | 200-500 ug IV (diagnostic) |
| Frequency | Diagnostic: single dose | Single dose (diagnostic) |
| Route | IV (clinical); ICV (research) | IV (diagnostic) |
| FDA Status | FDA approved (Acthrel for diagnostic use) | FDA approved (Thypinone for diagnostic use) |
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For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.