Side-by-Side Comparison · 2026

Cortistatin-14 vs PACAP

Cortistatin-14 vs PACAP — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortistatin-14
Neuropeptide / Neuromodulator

Cortistatin-14 (CST-14) is a cyclic neuropeptide with strong structural homology to somatostatin-14, sharing 11 of 14 residues. It activates all five somatostatin receptors (SSTR1-5) with similar affinity to somatostatin, but also binds additional receptors including the ghrelin ...

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PACAP
Neuropeptide / Neuromodulator

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide belonging to the secretin/glucagon/VIP superfamily. It was originally isolated from ovine hypothalamus for its ability to stimulate adenylate cyclase in pituitary cells....

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Key Parameters
Parameter Cortistatin-14 PACAP
Category Neuropeptide / Neuromodulator Neuropeptide / Neuromodulator
Research Preclinical Preclinical / Phase 2
Half-Life Short (minutes) 3-10 minutes (IV)
Typical Dose N/A (preclinical) 1-10 pmol/kg/min (IV research)
Frequency N/A Variable
Route ICV / IV (research) IV / SC / Intranasal (research)
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Cortistatin-14 and PACAP?
Cortistatin-14: Cortistatin-14 (CST-14) is a cyclic neuropeptide with strong structural homology to somatostatin-14, sharing 11 of 14 residues. It activates all five somatostatin receptors (SSTR1-5) with similar affi... PACAP: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide belonging to the secretin/glucagon/VIP superfamily. It was originally isolated from ovine hypothalamus for its ...
Which has a longer half-life, Cortistatin-14 or PACAP?
Cortistatin-14 half-life: Short (minutes). PACAP half-life: 3-10 minutes (IV).
Can you stack Cortistatin-14 and PACAP?
Cortistatin-14 and PACAP are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.