Side-by-Side Comparison · 2026

Cortistatin-14 vs Neuromedin S

Cortistatin-14 vs Neuromedin S — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortistatin-14
Neuropeptide

Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistatin has distinct receptor binding and biological actions....

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Neuromedin S
Neuropeptide

Neuromedin S (NMS) is a 36-amino acid amidated neuropeptide discovered in 2005 that shares a C-terminal amino acid sequence with neuromedin U (NMU) and activates the same NMUR1 and NMUR2 receptors. However, NMS has a markedly different expression pattern: while NMU is broadly exp...

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Key Parameters
Parameter Cortistatin-14 Neuromedin S
Category Neuropeptide Neuropeptide
Research Research Research
Half-Life Short (minutes) Short (minutes, estimated)
Typical Dose 250-500 mcg (animal) 1-10 nmol (central, animal)
Frequency Variable Variable
Route Subcutaneous, Intraperitoneal Intracerebroventricular, Subcutaneous
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Cortistatin-14 and Neuromedin S?
Cortistatin-14: Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistat... Neuromedin S: Neuromedin S (NMS) is a 36-amino acid amidated neuropeptide discovered in 2005 that shares a C-terminal amino acid sequence with neuromedin U (NMU) and activates the same NMUR1 and NMUR2 receptors. Ho...
Which has a longer half-life, Cortistatin-14 or Neuromedin S?
Cortistatin-14 half-life: Short (minutes). Neuromedin S half-life: Short (minutes, estimated).
Can you stack Cortistatin-14 and Neuromedin S?
Cortistatin-14 and Neuromedin S are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.