Side-by-Side Comparison · 2026

Cortistatin-14 vs Neuropeptide FF

Cortistatin-14 vs Neuropeptide FF — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortistatin-14
Neuropeptide

Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistatin has distinct receptor binding and biological actions....

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Neuropeptide FF
Neuropeptide

Neuropeptide FF (NPFF) is an endogenous octapeptide first isolated from bovine brain in 1985 and recognized as a key endogenous anti-opioid system component. NPFF is produced in the hypothalamus, brain stem, and spinal cord and acts on NPFF1 and NPFF2 receptors (GPCRs) to oppose ...

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Key Parameters
Parameter Cortistatin-14 Neuropeptide FF
Category Neuropeptide Neuropeptide
Research Research Research
Half-Life Short (minutes) Short (minutes)
Typical Dose 250-500 mcg (animal) 0.1-10 nmol (central, animal)
Frequency Variable Variable
Route Subcutaneous, Intraperitoneal Intrathecal, Intracerebroventricular (research)
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Cortistatin-14 and Neuropeptide FF?
Cortistatin-14: Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistat... Neuropeptide FF: Neuropeptide FF (NPFF) is an endogenous octapeptide first isolated from bovine brain in 1985 and recognized as a key endogenous anti-opioid system component. NPFF is produced in the hypothalamus, brai...
Which has a longer half-life, Cortistatin-14 or Neuropeptide FF?
Cortistatin-14 half-life: Short (minutes). Neuropeptide FF half-life: Short (minutes).
Can you stack Cortistatin-14 and Neuropeptide FF?
Cortistatin-14 and Neuropeptide FF are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.