Side-by-Side Comparison · 2026

Cortistatin-14 vs Neuropeptide S

Cortistatin-14 vs Neuropeptide S — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortistatin-14
Neuropeptide

Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistatin has distinct receptor binding and biological actions....

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Neuropeptide S
Neuropeptide

Neuropeptide S (NPS) is a 20-amino acid peptide discovered in 2004 that acts on the NPS receptor (NPSR1), a Gq/Gs-coupled GPCR with highest expression in amygdala, hypothalamus, and brainstem arousal centers. NPS produces a distinctive combination of simultaneous wakefulness prom...

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Key Parameters
Parameter Cortistatin-14 Neuropeptide S
Category Neuropeptide Neuropeptide
Research Research Preclinical
Half-Life Short (minutes) Short (minutes, CNS)
Typical Dose 250-500 mcg (animal) 0.1-10 nmol (ICV, animal)
Frequency Variable Variable
Route Subcutaneous, Intraperitoneal Intracerebroventricular (animal research)
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Cortistatin-14 and Neuropeptide S?
Cortistatin-14: Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistat... Neuropeptide S: Neuropeptide S (NPS) is a 20-amino acid peptide discovered in 2004 that acts on the NPS receptor (NPSR1), a Gq/Gs-coupled GPCR with highest expression in amygdala, hypothalamus, and brainstem arousal ...
Which has a longer half-life, Cortistatin-14 or Neuropeptide S?
Cortistatin-14 half-life: Short (minutes). Neuropeptide S half-life: Short (minutes, CNS).
Can you stack Cortistatin-14 and Neuropeptide S?
Cortistatin-14 and Neuropeptide S are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.