Side-by-Side Comparison · 2026

Cortistatin-14 vs Relaxin-3

Cortistatin-14 vs Relaxin-3 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortistatin-14
Neuropeptide

Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistatin has distinct receptor binding and biological actions....

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Relaxin-3
Neuropeptide

Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stress, arousal, and hippocampal theta rhythm generation. Unlike relaxin-1 and relax...

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Key Parameters
Parameter Cortistatin-14 Relaxin-3
Category Neuropeptide Neuropeptide
Research Research Preclinical Research
Half-Life Short (minutes) ~30-60 minutes (estimated)
Typical Dose 250-500 mcg (animal) 100-500 pmol ICV; 1-3 nmol/kg SC
Frequency Variable Single or twice daily (preclinical)
Route Subcutaneous, Intraperitoneal ICV, SC (preclinical)
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Cortistatin-14 and Relaxin-3?
Cortistatin-14: Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistat... Relaxin-3: Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stre...
Which has a longer half-life, Cortistatin-14 or Relaxin-3?
Cortistatin-14 half-life: Short (minutes). Relaxin-3 half-life: ~30-60 minutes (estimated).
Can you stack Cortistatin-14 and Relaxin-3?
Cortistatin-14 and Relaxin-3 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.