Side-by-Side Comparison · 2026

Cortistatin-14 vs TLQP-21

Cortistatin-14 vs TLQP-21 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cortistatin-14
Neuropeptide

Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistatin has distinct receptor binding and biological actions....

Calculate Cortistatin-14 dose →
TLQP-21
Neuropeptide

TLQP-21 is a 21-amino acid peptide derived from the C-terminal region of VGF (Nerve Growth Factor-Inducible), a large precursor neuropeptide that is proteolytically cleaved into multiple bioactive fragments. VGF is strongly induced by NGF and BDNF and plays roles in energy homeos...

Calculate TLQP-21 dose →
Key Parameters
Parameter Cortistatin-14 TLQP-21
Category Neuropeptide Neuropeptide
Research Research Research
Half-Life Short (minutes) Unknown
Typical Dose 250-500 mcg (animal) 1-100 nmol (animal)
Frequency Variable Variable
Route Subcutaneous, Intraperitoneal Intrathecal, Subcutaneous, Intracerebroventricular
FDA Status Not approved Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Cortistatin-14 Calculate TLQP-21
Frequently Asked Questions
What is the difference between Cortistatin-14 and TLQP-21?
Cortistatin-14: Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistat... TLQP-21: TLQP-21 is a 21-amino acid peptide derived from the C-terminal region of VGF (Nerve Growth Factor-Inducible), a large precursor neuropeptide that is proteolytically cleaved into multiple bioactive fra...
Which has a longer half-life, Cortistatin-14 or TLQP-21?
Cortistatin-14 half-life: Short (minutes). TLQP-21 half-life: Unknown.
Can you stack Cortistatin-14 and TLQP-21?
Cortistatin-14 and TLQP-21 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.