Side-by-Side Comparison · 2026

CRH vs GHRH

CRH vs GHRH — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

CRH
Hypothalamic Hormone

Corticotropin-releasing hormone (CRH, also CRF) is a 41-amino acid hypothalamic peptide first isolated by Vale et al. in 1981 after 40 years of searching....

Calculate CRH dose →
GHRH
Hypothalamic Hormone

Growth hormone-releasing hormone (GHRH) is a 44-amino acid hypothalamic peptide that stimulates GH synthesis and pulsatile release from anterior pituitary somatotrophs. It acts via GHRH receptor (GHRHR), a Gs-coupled GPCR, to elevate cAMP and drive GH secretion....

Calculate GHRH dose →
Key Parameters
Parameter CRH GHRH
Category Hypothalamic Hormone Hypothalamic Hormone
Research Clinical FDA Approved (via analogs)
Half-Life 60-73 min (plasma) ~7 min (plasma)
Typical Dose 1 mcg/kg IV (CRH stimulation test) Sermorelin: 0.2-0.3 mg SC at bedtime
Frequency Single diagnostic dose or research protocol Daily (sermorelin)
Route Intravenous (diagnostic), Subcutaneous IV, SC
FDA Status Approved (Acthrel, diagnostic use) Sermorelin (GHRH 1-29) FDA approved for pediatric GH deficiency

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate CRH Calculate GHRH
Frequently Asked Questions
What is the difference between CRH and GHRH?
CRH: Corticotropin-releasing hormone (CRH, also CRF) is a 41-amino acid hypothalamic peptide first isolated by Vale et al. in 1981 after 40 years of searching.... GHRH: Growth hormone-releasing hormone (GHRH) is a 44-amino acid hypothalamic peptide that stimulates GH synthesis and pulsatile release from anterior pituitary somatotrophs. It acts via GHRH receptor (GHRH...
Which has a longer half-life, CRH or GHRH?
CRH half-life: 60-73 min (plasma). GHRH half-life: ~7 min (plasma).
Can you stack CRH and GHRH?
CRH and GHRH are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.