Side-by-Side Comparison · 2026

Human Neutrophil Peptide 1 vs Kalata B1

Human Neutrophil Peptide 1 vs Kalata B1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Human Neutrophil Peptide 1
Antimicrobial Peptide

Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are the human versions of the ancestral defensin family....

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Kalata B1
Antimicrobial Peptide

Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis, which is traditionally used in Africa to accelerate childbirth (uterotonic use)...

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Key Parameters
Parameter Human Neutrophil Peptide 1 Kalata B1
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (in tissues) Hours (resistant to all proteases)
Typical Dose N/A N/A
Frequency N/A N/A
Route Endogenous (secreted by neutrophils) / Research only Research only (oral stability under study)
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Human Neutrophil Peptide 1 and Kalata B1?
Human Neutrophil Peptide 1: Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are ... Kalata B1: Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis,...
Which has a longer half-life, Human Neutrophil Peptide 1 or Kalata B1?
Human Neutrophil Peptide 1 half-life: Hours (in tissues). Kalata B1 half-life: Hours (resistant to all proteases).
Can you stack Human Neutrophil Peptide 1 and Kalata B1?
Human Neutrophil Peptide 1 and Kalata B1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.