Side-by-Side Comparison · 2026

Human Neutrophil Peptide 1 vs Omiganan

Human Neutrophil Peptide 1 vs Omiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Human Neutrophil Peptide 1
Antimicrobial Peptide

Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are the human versions of the ancestral defensin family....

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Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Key Parameters
Parameter Human Neutrophil Peptide 1 Omiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase 3 (Completed)
Half-Life Hours (in tissues) Hours (topical)
Typical Dose N/A 1-3% gel
Frequency N/A Twice daily
Route Endogenous (secreted by neutrophils) / Research only Topical gel/cream
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Human Neutrophil Peptide 1 and Omiganan?
Human Neutrophil Peptide 1: Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are ... Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve...
Which has a longer half-life, Human Neutrophil Peptide 1 or Omiganan?
Human Neutrophil Peptide 1 half-life: Hours (in tissues). Omiganan half-life: Hours (topical).
Can you stack Human Neutrophil Peptide 1 and Omiganan?
Human Neutrophil Peptide 1 and Omiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.