Side-by-Side Comparison · 2026

Human Neutrophil Peptide 1 vs Phylloseptin

Human Neutrophil Peptide 1 vs Phylloseptin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Human Neutrophil Peptide 1
Antimicrobial Peptide

Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are the human versions of the ancestral defensin family....

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Phylloseptin
Antimicrobial Peptide

Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins from the same genus, phylloseptins are shorter (19 residues) and show a distinct...

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Key Parameters
Parameter Human Neutrophil Peptide 1 Phylloseptin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (in tissues) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Endogenous (secreted by neutrophils) / Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Human Neutrophil Peptide 1 and Phylloseptin?
Human Neutrophil Peptide 1: Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are ... Phylloseptin: Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial peptides isolated from the skin secretions of South American Phyllomedusa frogs. Unlike the related dermaseptins ...
Which has a longer half-life, Human Neutrophil Peptide 1 or Phylloseptin?
Human Neutrophil Peptide 1 half-life: Hours (in tissues). Phylloseptin half-life: Minutes (proteolytic).
Can you stack Human Neutrophil Peptide 1 and Phylloseptin?
Human Neutrophil Peptide 1 and Phylloseptin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.