Side-by-Side Comparison · 2026

Human Neutrophil Peptide 1 vs Plectasin

Human Neutrophil Peptide 1 vs Plectasin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Human Neutrophil Peptide 1
Antimicrobial Peptide

Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are the human versions of the ancestral defensin family....

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Plectasin
Antimicrobial Peptide

Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....

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Key Parameters
Parameter Human Neutrophil Peptide 1 Plectasin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (in tissues) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Endogenous (secreted by neutrophils) / Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Human Neutrophil Peptide 1 and Plectasin?
Human Neutrophil Peptide 1: Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil granules, where it constitutes up to 30% of total protein content. Alpha-defensins HNP-1, -2, -3, and -4 are ... Plectasin: Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the saprophytic fungus Pseudoplectania nigrella. It was the first AMP isolated from a fungal organism....
Which has a longer half-life, Human Neutrophil Peptide 1 or Plectasin?
Human Neutrophil Peptide 1 half-life: Hours (in tissues). Plectasin half-life: Hours (disulfide stabilized).
Can you stack Human Neutrophil Peptide 1 and Plectasin?
Human Neutrophil Peptide 1 and Plectasin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.