Side-by-Side Comparison · 2026

Defensin vs Protegrin

Defensin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Defensin
Antimicrobial Peptide

Defensins are a superfamily of small, cysteine-rich cationic antimicrobial peptides that form a critical component of innate immunity across virtually all multicellular organisms. In humans, alpha-defensins (HNP-1 to -4 in neutrophils; HD-5, HD-6 in intestinal Paneth cells) and b...

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Defensin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Research/Therapeutic Development Phase III (failed)
Half-Life Minutes-hours (tissue dependent) Hours (disulfide stabilized)
Typical Dose Research only N/A
Frequency N/A N/A
Route Endogenous; topical/intranasal (research) Topical / Rinse
FDA Status No approval (research stage) Not approved

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Frequently Asked Questions
What is the difference between Defensin and Protegrin?
Defensin: Defensins are a superfamily of small, cysteine-rich cationic antimicrobial peptides that form a critical component of innate immunity across virtually all multicellular organisms. In humans, alpha-def... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Defensin or Protegrin?
Defensin half-life: Minutes-hours (tissue dependent). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Defensin and Protegrin?
Defensin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.