Side-by-Side Comparison · 2026

Dermaseptin vs Protegrin

Dermaseptin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Dermaseptin
Antimicrobial Peptide

Dermaseptins are a family of 28-34 amino acid antimicrobial peptides first isolated from the skin of South American Phyllomedusa frogs. They are among the most potent broad-spectrum AMPs known, with activity against bacteria, fungi, protozoa, and viruses....

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Dermaseptin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase III (failed)
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A (research) N/A
Frequency N/A N/A
Route Topical / Parenteral (research) Topical / Rinse
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Dermaseptin and Protegrin?
Dermaseptin: Dermaseptins are a family of 28-34 amino acid antimicrobial peptides first isolated from the skin of South American Phyllomedusa frogs. They are among the most potent broad-spectrum AMPs known, with a... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Dermaseptin or Protegrin?
Dermaseptin half-life: Minutes (proteolytic). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Dermaseptin and Protegrin?
Dermaseptin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.