Side-by-Side Comparison · 2026

Elabela vs Intermedin

Elabela vs Intermedin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Elabela
Cardiovascular Peptide

Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac development factor (Toddler) and as a novel human APJ ligand (Elabela). Unlike apelin pe...

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Intermedin
Cardiovascular Peptide

Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widely expressed in the heart, lung, kidney, gut, and brain....

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Key Parameters
Parameter Elabela Intermedin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Research Preclinical Research
Half-Life Short (minutes, estimated) ~15-30 minutes
Typical Dose 5-500 nmol/kg (animal) 1-100 pmol/kg/min infusion (animal)
Frequency Variable Acute infusion
Route Subcutaneous, Intravenous IV (research); SC in some studies
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Elabela and Intermedin?
Elabela: Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac developm... Intermedin: Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widel...
Which has a longer half-life, Elabela or Intermedin?
Elabela half-life: Short (minutes, estimated). Intermedin half-life: ~15-30 minutes.
Can you stack Elabela and Intermedin?
Elabela and Intermedin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.