Side-by-Side Comparison · 2026

Elabela vs Relaxin-2

Elabela vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Elabela
Cardiovascular Peptide

Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac development factor (Toddler) and as a novel human APJ ligand (Elabela). Unlike apelin pe...

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Elabela Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Research Clinical
Half-Life Short (minutes, estimated) 10-15 min (plasma)
Typical Dose 5-500 nmol/kg (animal) 30-300 mcg/kg/day (IV)
Frequency Variable Continuous 48-hour infusion (trials)
Route Subcutaneous, Intravenous Intravenous (infusion)
FDA Status Not approved Not approved (Phase III completed)

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Frequently Asked Questions
What is the difference between Elabela and Relaxin-2?
Elabela: Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac developm... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Elabela or Relaxin-2?
Elabela half-life: Short (minutes, estimated). Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Elabela and Relaxin-2?
Elabela and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.