Side-by-Side Comparison · 2026

Epithalon vs MOTS-c

Epithalon vs MOTS-c — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Epithalon
Longevity & Telomere

Epithalon is a synthetic tetrapeptide derived from the pineal gland bioregulator Epithalamin. It activates telomerase to extend telomeres and slow cellular senescence, and regulates melatonin production and circadian rhythm. Administered in 10-20 day courses 2-3 times yearly. The...

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MOTS-c
Mitochondrial & Longevity

MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within mitochondrial DNA, functioning as a mitohormone. It enhances insulin sensitivity, improves exercise capacity, and may extend healthspan. Plasma levels decline with age and metabolic disease. Phase I research s...

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Key Parameters
Parameter Epithalon MOTS-c
Category Longevity & Telomere Mitochondrial & Longevity
Research Extensively Studied Extensively Studied
Half-Life ~30 min 4 hours
Typical Dose 5–10 mg 5–15 mg
Frequency Once daily × 10–20 days (cycle) Daily or 3× per week
Route Subcutaneous / IV Subcutaneous
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between Epithalon and MOTS-c?
Epithalon: Epithalon is a synthetic tetrapeptide derived from the pineal gland bioregulator Epithalamin. It activates telomerase to extend telomeres and slow cellular senescence, and regulates melatonin producti... MOTS-c: MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within mitochondrial DNA, functioning as a mitohormone. It enhances insulin sensitivity, improves exercise capacity, and may extend heal...
Which has a longer half-life, Epithalon or MOTS-c?
Epithalon half-life: ~30 min. MOTS-c half-life: 4 hours.
Can you stack Epithalon and MOTS-c?
Epithalon and MOTS-c are sometimes used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.