Side-by-Side Comparison · 2026

Esculentin vs Polyphemusin

Esculentin vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Esculentin
Antimicrobial Peptide

Esculentins are the longest known naturally occurring antimicrobial peptides, isolated from the skin of the water frog Rana esculenta. At 46 amino acids, they form two amphipathic helices connected by a short linker....

Calculate Esculentin dose →
Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

Calculate Polyphemusin dose →
Key Parameters
Parameter Esculentin Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Esculentin Calculate Polyphemusin
Frequently Asked Questions
What is the difference between Esculentin and Polyphemusin?
Esculentin: Esculentins are the longest known naturally occurring antimicrobial peptides, isolated from the skin of the water frog Rana esculenta. At 46 amino acids, they form two amphipathic helices connected by... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, Esculentin or Polyphemusin?
Esculentin half-life: Minutes (proteolytic). Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack Esculentin and Polyphemusin?
Esculentin and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.