Side-by-Side Comparison · 2026

Esculentin vs PR-39

Esculentin vs PR-39 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Esculentin
Antimicrobial Peptide

Esculentins are the longest known naturally occurring antimicrobial peptides, isolated from the skin of the water frog Rana esculenta. At 46 amino acids, they form two amphipathic helices connected by a short linker....

Calculate Esculentin dose →
PR-39
Antimicrobial Peptide

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting DNA and protein synthesis....

Calculate PR-39 dose →
Key Parameters
Parameter Esculentin PR-39
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Esculentin Calculate PR-39
Frequently Asked Questions
What is the difference between Esculentin and PR-39?
Esculentin: Esculentins are the longest known naturally occurring antimicrobial peptides, isolated from the skin of the water frog Rana esculenta. At 46 amino acids, they form two amphipathic helices connected by... PR-39: PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting D...
Which has a longer half-life, Esculentin or PR-39?
Esculentin half-life: Minutes (proteolytic). PR-39 half-life: Minutes (proteolytic).
Can you stack Esculentin and PR-39?
Esculentin and PR-39 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.