Side-by-Side Comparison · 2026

GDF-11 vs N-Acetyl Epithalon Amidate

GDF-11 vs N-Acetyl Epithalon Amidate — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

GDF-11
Anti-aging & Longevity

Growth Differentiation Factor 11 (GDF-11) is a member of the TGF-beta superfamily that gained significant attention following a series of parabiosis studies from Harvard/Stanford labs published in Cell and Science (2013-2014) suggesting that circulating GDF-11 declines with age a...

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N-Acetyl Epithalon Amidate
Anti-aging & Longevity

N-Acetyl Epithalon Amidate is a chemically modified form of Epithalon (Ala-Glu-Pro-Gly) in which the free amino terminus is capped with an acetyl group and the C-terminal carboxyl is converted to an amide. These two modifications collectively prevent degradation by aminopeptidase...

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Key Parameters
Parameter GDF-11 N-Acetyl Epithalon Amidate
Category Anti-aging & Longevity Anti-aging & Longevity
Research Actively Researched (Controversial) Preclinical / Derivative of Extensively Studied Parent
Half-Life Hours (IV); extended SC 4-6 h (estimated; longer than unmodified)
Typical Dose 100-150 mcg, 1-2x/week 5-10 mg per course
Frequency 1-2 times per week Daily (course-based)
Route Subcutaneous, IV Subcutaneous, Oral (enhanced vs parent)
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between GDF-11 and N-Acetyl Epithalon Amidate?
GDF-11: Growth Differentiation Factor 11 (GDF-11) is a member of the TGF-beta superfamily that gained significant attention following a series of parabiosis studies from Harvard/Stanford labs published in Cel... N-Acetyl Epithalon Amidate: N-Acetyl Epithalon Amidate is a chemically modified form of Epithalon (Ala-Glu-Pro-Gly) in which the free amino terminus is capped with an acetyl group and the C-terminal carboxyl is converted to an a...
Which has a longer half-life, GDF-11 or N-Acetyl Epithalon Amidate?
GDF-11 half-life: Hours (IV); extended SC. N-Acetyl Epithalon Amidate half-life: 4-6 h (estimated; longer than unmodified).
Can you stack GDF-11 and N-Acetyl Epithalon Amidate?
GDF-11 and N-Acetyl Epithalon Amidate are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.