Side-by-Side Comparison · 2026

GHK vs Matrixyl

GHK vs Matrixyl — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

GHK
Skin & Cosmetic

GHK (Glycyl-L-Histidyl-L-Lysine) is the copper-free form of the GHK-Cu tripeptide. While GHK-Cu (GHK chelated to copper) is more widely studied for wound healing and tissue repair, GHK alone retains some bioactivity, particularly for signaling collagen synthesis and gene expressi...

Calculate GHK dose →
Matrixyl
Skin & Cosmetic

Matrixyl is the trade name for Palmitoyl Pentapeptide-4 (Pal-KTTKS), developed by Sederma (now Croda). It is derived from a procollagen type I C-terminal propeptide fragment and uses palmitoylation to cross the skin lipid barrier and reach dermal fibroblasts....

Calculate Matrixyl dose →
Key Parameters
Parameter GHK Matrixyl
Category Skin & Cosmetic Skin & Cosmetic
Research Research Use Widely Used (Cosmetic)
Half-Life - -
Typical Dose 1–5% topical; 1–2 mg/mL injectable 3–5% in formulation
Frequency Once or twice daily Twice daily
Route Topical / Injectable Topical
FDA Status Not Approved (Cosmetic) Not Approved (Cosmetic)

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate GHK Calculate Matrixyl
Frequently Asked Questions
What is the difference between GHK and Matrixyl?
GHK: GHK (Glycyl-L-Histidyl-L-Lysine) is the copper-free form of the GHK-Cu tripeptide. While GHK-Cu (GHK chelated to copper) is more widely studied for wound healing and tissue repair, GHK alone retains s... Matrixyl: Matrixyl is the trade name for Palmitoyl Pentapeptide-4 (Pal-KTTKS), developed by Sederma (now Croda). It is derived from a procollagen type I C-terminal propeptide fragment and uses palmitoylation to...
Which has a longer half-life, GHK or Matrixyl?
GHK half-life: unknown. Matrixyl half-life: unknown.
Can you stack GHK and Matrixyl?
GHK and Matrixyl are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.