Side-by-Side Comparison · 2026

Gramicidin A vs Gramicidin S

Gramicidin A vs Gramicidin S — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Gramicidin A
Antimicrobial Peptide

Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in Neosporin and other topical antibiotic combinations....

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Gramicidin S
Antimicrobial Peptide

Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topical wound antiseptic for Soviet forces....

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Key Parameters
Parameter Gramicidin A Gramicidin S
Category Antimicrobial Peptide Antimicrobial Peptide
Research Approved (topical combination) Approved (topical, certain countries)
Half-Life Hours (membrane-bound) Hours (topical)
Typical Dose Component of Neosporin and similar products 0.1-0.5% in topical preparations
Frequency As needed As needed
Route Topical (combination products) Topical
FDA Status Approved (topical combination) Not FDA approved (approved in USSR/Russia, used in Europe)

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Frequently Asked Questions
What is the difference between Gramicidin A and Gramicidin S?
Gramicidin A: Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in N... Gramicidin S: Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topic...
Which has a longer half-life, Gramicidin A or Gramicidin S?
Gramicidin A half-life: Hours (membrane-bound). Gramicidin S half-life: Hours (topical).
Can you stack Gramicidin A and Gramicidin S?
Gramicidin A and Gramicidin S are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.