Side-by-Side Comparison · 2026

Gramicidin A vs Ponericin

Gramicidin A vs Ponericin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Gramicidin A
Antimicrobial Peptide

Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in Neosporin and other topical antibiotic combinations....

Calculate Gramicidin A dose →
Ponericin
Antimicrobial Peptide

Ponericins are a family of antimicrobial peptides isolated from the venom of the ant Pachycondyla goeldii. They adopt alpha-helical conformations in membrane environments and display broad-spectrum antibacterial and insecticidal activity....

Calculate Ponericin dose →
Key Parameters
Parameter Gramicidin A Ponericin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Approved (topical combination) Preclinical
Half-Life Hours (membrane-bound) Short
Typical Dose Component of Neosporin and similar products N/A (research only)
Frequency As needed N/A
Route Topical (combination products) Topical / Systemic (research)
FDA Status Approved (topical combination) Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Gramicidin A Calculate Ponericin
Frequently Asked Questions
What is the difference between Gramicidin A and Ponericin?
Gramicidin A: Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in N... Ponericin: Ponericins are a family of antimicrobial peptides isolated from the venom of the ant Pachycondyla goeldii. They adopt alpha-helical conformations in membrane environments and display broad-spectrum an...
Which has a longer half-life, Gramicidin A or Ponericin?
Gramicidin A half-life: Hours (membrane-bound). Ponericin half-life: Short.
Can you stack Gramicidin A and Ponericin?
Gramicidin A and Ponericin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.