Side-by-Side Comparison · 2026

Gramicidin A vs Protegrin-1

Gramicidin A vs Protegrin-1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Gramicidin A
Antimicrobial Peptide

Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in Neosporin and other topical antibiotic combinations....

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Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

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Key Parameters
Parameter Gramicidin A Protegrin-1
Category Antimicrobial Peptide Antimicrobial Peptide
Research Approved (topical combination) Phase 3 / Clinical
Half-Life Hours (membrane-bound) Short
Typical Dose Component of Neosporin and similar products 0.1-1 mg/mL (topical)
Frequency As needed BID-TID
Route Topical (combination products) Topical / Oral rinse (research)
FDA Status Approved (topical combination) Phase 3 clinical evaluation (iseganan)

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Frequently Asked Questions
What is the difference between Gramicidin A and Protegrin-1?
Gramicidin A: Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in N... Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat...
Which has a longer half-life, Gramicidin A or Protegrin-1?
Gramicidin A half-life: Hours (membrane-bound). Protegrin-1 half-life: Short.
Can you stack Gramicidin A and Protegrin-1?
Gramicidin A and Protegrin-1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.