Side-by-Side Comparison · 2026

Gramicidin S vs Protegrin-1

Gramicidin S vs Protegrin-1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Gramicidin S
Antimicrobial Peptide

Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topical wound antiseptic for Soviet forces....

Calculate Gramicidin S dose →
Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

Calculate Protegrin-1 dose →
Key Parameters
Parameter Gramicidin S Protegrin-1
Category Antimicrobial Peptide Antimicrobial Peptide
Research Approved (topical, certain countries) Phase 3 / Clinical
Half-Life Hours (topical) Short
Typical Dose 0.1-0.5% in topical preparations 0.1-1 mg/mL (topical)
Frequency As needed BID-TID
Route Topical Topical / Oral rinse (research)
FDA Status Not FDA approved (approved in USSR/Russia, used in Europe) Phase 3 clinical evaluation (iseganan)

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Gramicidin S Calculate Protegrin-1
Frequently Asked Questions
What is the difference between Gramicidin S and Protegrin-1?
Gramicidin S: Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topic... Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat...
Which has a longer half-life, Gramicidin S or Protegrin-1?
Gramicidin S half-life: Hours (topical). Protegrin-1 half-life: Short.
Can you stack Gramicidin S and Protegrin-1?
Gramicidin S and Protegrin-1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.