Side-by-Side Comparison · 2026

Gramicidin S vs Ramoplanin

Gramicidin S vs Ramoplanin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Gramicidin S
Antimicrobial Peptide

Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topical wound antiseptic for Soviet forces....

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Ramoplanin
Antimicrobial Peptide

Ramoplanin is a glycodepsipeptide antibiotic produced by Actinoplanes sp. ATCC 33076 with potent activity against gram-positive bacteria....

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Key Parameters
Parameter Gramicidin S Ramoplanin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Approved (topical, certain countries) Phase 3 (Discontinued)
Half-Life Hours (topical) Short (gut lumen)
Typical Dose 0.1-0.5% in topical preparations 200 mg twice daily
Frequency As needed Twice daily
Route Topical Oral (non-absorbed)
FDA Status Not FDA approved (approved in USSR/Russia, used in Europe) Not approved (Phase 3 discontinued)

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Frequently Asked Questions
What is the difference between Gramicidin S and Ramoplanin?
Gramicidin S: Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topic... Ramoplanin: Ramoplanin is a glycodepsipeptide antibiotic produced by Actinoplanes sp. ATCC 33076 with potent activity against gram-positive bacteria....
Which has a longer half-life, Gramicidin S or Ramoplanin?
Gramicidin S half-life: Hours (topical). Ramoplanin half-life: Short (gut lumen).
Can you stack Gramicidin S and Ramoplanin?
Gramicidin S and Ramoplanin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.