Side-by-Side Comparison · 2026

HCG vs HMG

HCG vs HMG — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

HCG
Hormonal & Reproductive

Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone naturally produced by the placenta during pregnancy. Its alpha subunit is structurally identical to LH (luteinizing hormone), FSH, and TSH; its beta subunit is unique and gives it LH-like activity....

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HMG
Hormonal & Reproductive

Human Menopausal Gonadotropin (hMG) is a purified preparation of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) extracted from the urine of postmenopausal women. It is used in fertility treatment to stimulate follicular development in females (controlled ovarian ...

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Key Parameters
Parameter HCG HMG
Category Hormonal & Reproductive Hormonal & Reproductive
Research FDA Approved FDA Approved
Half-Life 24–36 hours FSH ~4 hrs; LH ~1 hr
Typical Dose 250–500 IU (TRT support); 1,000–5,000 IU (fertility) 75–225 IU per day
Frequency 2–3x weekly (TRT); varies by fertility protocol Daily (fertility protocol)
Route Subcutaneous / Intramuscular Subcutaneous / Intramuscular
FDA Status Approved Approved

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Frequently Asked Questions
What is the difference between HCG and HMG?
HCG: Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone naturally produced by the placenta during pregnancy. Its alpha subunit is structurally identical to LH (luteinizing hormone), FSH, and TSH;... HMG: Human Menopausal Gonadotropin (hMG) is a purified preparation of FSH (follicle-stimulating hormone) and LH (luteinizing hormone) extracted from the urine of postmenopausal women. It is used in fertili...
Which has a longer half-life, HCG or HMG?
HCG half-life: 24–36 hours. HMG half-life: FSH ~4 hrs; LH ~1 hr.
Can you stack HCG and HMG?
HCG and HMG are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.