Side-by-Side Comparison · 2026

Hexarelin vs Sermorelin

Hexarelin vs Sermorelin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Hexarelin
Growth Hormone

Hexarelin (Examorelin) is the most potent GHRP in clinical research, producing the largest GH pulses per microgram of any peptide in its class. Its methylated tryptophan residue (2-MeTrp) compared to GHRP-6 accounts for its increased potency....

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Sermorelin
Growth Hormone

Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from 1997 until its voluntary market withdrawal in 2008 for commercial reasons - not...

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Key Parameters
Parameter Hexarelin Sermorelin
Category Growth Hormone Growth Hormone
Research Extensively Studied Extensively Studied
Half-Life ~70 min ~10–20 min
Typical Dose 100–200 µg 200–500 µg
Frequency 1–3× daily Once daily (bedtime)
Route Subcutaneous Subcutaneous
FDA Status Not Approved Compounding Only

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Frequently Asked Questions
What is the difference between Hexarelin and Sermorelin?
Hexarelin: Hexarelin (Examorelin) is the most potent GHRP in clinical research, producing the largest GH pulses per microgram of any peptide in its class. Its methylated tryptophan residue (2-MeTrp) compared to ... Sermorelin: Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from...
Which has a longer half-life, Hexarelin or Sermorelin?
Hexarelin half-life: ~70 min. Sermorelin half-life: ~10–20 min.
Can you stack Hexarelin and Sermorelin?
Hexarelin and Sermorelin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.