Side-by-Side Comparison · 2026

IGF-1 DES vs MGF

IGF-1 DES vs MGF — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

IGF-1 DES
Growth Hormone & IGF

IGF-1 DES (des(1-3)IGF-1) is a naturally occurring truncated form of IGF-1, produced endogenously in the brain and other tissues, that lacks the first three N-terminal amino acids (Gly-Pro-Glu) of full-length IGF-1. This truncation eliminates its binding to IGF-binding proteins (...

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MGF
Growth Hormone & IGF

Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced locally in mechanically stressed muscle tissue (IGF-1Ec isoform). It is generated when the IGF-1 gene is alternatively spliced in response to muscle damage or exercise-induced mechanical loading....

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Key Parameters
Parameter IGF-1 DES MGF
Category Growth Hormone & IGF Growth Hormone & IGF
Research Research Use Research Use
Half-Life 20–30 minutes (shorter than IGF-1 LR3) ~5–7 minutes (non-PEGylated)
Typical Dose 50–100 µg 100–200 µg
Frequency 1–2x daily (peri-workout) Post-workout, 3–5x/week
Route Subcutaneous / Intramuscular (local) Subcutaneous / Intramuscular (local)
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between IGF-1 DES and MGF?
IGF-1 DES: IGF-1 DES (des(1-3)IGF-1) is a naturally occurring truncated form of IGF-1, produced endogenously in the brain and other tissues, that lacks the first three N-terminal amino acids (Gly-Pro-Glu) of ful... MGF: Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced locally in mechanically stressed muscle tissue (IGF-1Ec isoform). It is generated when the IGF-1 gene is alternatively spliced in resp...
Which has a longer half-life, IGF-1 DES or MGF?
IGF-1 DES half-life: 20–30 minutes (shorter than IGF-1 LR3). MGF half-life: ~5–7 minutes (non-PEGylated).
Can you stack IGF-1 DES and MGF?
IGF-1 DES and MGF are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.