Side-by-Side Comparison · 2026

IGF-1 DES vs MK-677

IGF-1 DES vs MK-677 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

IGF-1 DES
Growth Hormone & IGF

IGF-1 DES (des(1-3)IGF-1) is a naturally occurring truncated form of IGF-1, produced endogenously in the brain and other tissues, that lacks the first three N-terminal amino acids (Gly-Pro-Glu) of full-length IGF-1. This truncation eliminates its binding to IGF-binding proteins (...

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MK-677
Growth Hormone & IGF

MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advanced through Phase II trials for growth hormone deficiency, muscle wasting, and fra...

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Key Parameters
Parameter IGF-1 DES MK-677
Category Growth Hormone & IGF Growth Hormone & IGF
Research Research Use Phase II (Discontinued)
Half-Life 20–30 minutes (shorter than IGF-1 LR3) ~24 hours
Typical Dose 50–100 µg 10–25 mg
Frequency 1–2x daily (peri-workout) Once daily
Route Subcutaneous / Intramuscular (local) Oral
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between IGF-1 DES and MK-677?
IGF-1 DES: IGF-1 DES (des(1-3)IGF-1) is a naturally occurring truncated form of IGF-1, produced endogenously in the brain and other tissues, that lacks the first three N-terminal amino acids (Gly-Pro-Glu) of ful... MK-677: MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advance...
Which has a longer half-life, IGF-1 DES or MK-677?
IGF-1 DES half-life: 20–30 minutes (shorter than IGF-1 LR3). MK-677 half-life: ~24 hours.
Can you stack IGF-1 DES and MK-677?
IGF-1 DES and MK-677 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.