Side-by-Side Comparison · 2026

IGF-1 LR3 vs MGF

IGF-1 LR3 vs MGF — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

IGF-1 LR3
Anabolic & GH Axis

IGF-1 LR3 is a recombinant IGF-1 analog with an N-terminal extension that reduces binding to IGF binding proteins by over 1000-fold, extending active half-life to 20-30 hours from 12-15 minutes. Drives muscle protein synthesis, satellite cell activation, and anti-catabolic signal...

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MGF
Growth Hormone & IGF

Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced locally in mechanically stressed muscle tissue (IGF-1Ec isoform). It is generated when the IGF-1 gene is alternatively spliced in response to muscle damage or exercise-induced mechanical loading....

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Key Parameters
Parameter IGF-1 LR3 MGF
Category Anabolic & GH Axis Growth Hormone & IGF
Research Extensively Studied Research Use
Half-Life ~20–30 hours ~5–7 minutes (non-PEGylated)
Typical Dose 20–100 µg 100–200 µg
Frequency Once daily Post-workout, 3–5x/week
Route Subcutaneous / Intramuscular Subcutaneous / Intramuscular (local)
FDA Status Not Approved Not Approved

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Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

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Frequently Asked Questions
What is the difference between IGF-1 LR3 and MGF?
IGF-1 LR3: IGF-1 LR3 is a recombinant IGF-1 analog with an N-terminal extension that reduces binding to IGF binding proteins by over 1000-fold, extending active half-life to 20-30 hours from 12-15 minutes. Drive... MGF: Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced locally in mechanically stressed muscle tissue (IGF-1Ec isoform). It is generated when the IGF-1 gene is alternatively spliced in resp...
Which has a longer half-life, IGF-1 LR3 or MGF?
IGF-1 LR3 half-life: ~20–30 hours. MGF half-life: ~5–7 minutes (non-PEGylated).
Can you stack IGF-1 LR3 and MGF?
IGF-1 LR3 and MGF are sometimes used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.