Side-by-Side Comparison · 2026

Indolicidin vs Polyphemusin

Indolicidin vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Indolicidin
Antimicrobial Peptide

Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil granules. It is the smallest naturally occurring AMP with broad-spectrum activity....

Calculate Indolicidin dose →
Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

Calculate Polyphemusin dose →
Key Parameters
Parameter Indolicidin Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase II (completed) Preclinical
Half-Life Minutes to hours Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Topical Research only
FDA Status Not approved Not approved

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Indolicidin Calculate Polyphemusin
Frequently Asked Questions
What is the difference between Indolicidin and Polyphemusin?
Indolicidin: Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil granules. It is the smallest naturally occurring AMP with broad-spectrum activity.... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, Indolicidin or Polyphemusin?
Indolicidin half-life: Minutes to hours. Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack Indolicidin and Polyphemusin?
Indolicidin and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.