Side-by-Side Comparison · 2026

Indolicidin vs PR-39

Indolicidin vs PR-39 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Indolicidin
Antimicrobial Peptide

Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil granules. It is the smallest naturally occurring AMP with broad-spectrum activity....

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PR-39
Antimicrobial Peptide

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting DNA and protein synthesis....

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Key Parameters
Parameter Indolicidin PR-39
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase II (completed) Preclinical
Half-Life Minutes to hours Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Topical Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Indolicidin and PR-39?
Indolicidin: Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil granules. It is the smallest naturally occurring AMP with broad-spectrum activity.... PR-39: PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting D...
Which has a longer half-life, Indolicidin or PR-39?
Indolicidin half-life: Minutes to hours. PR-39 half-life: Minutes (proteolytic).
Can you stack Indolicidin and PR-39?
Indolicidin and PR-39 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.