Side-by-Side Comparison · 2026

Indolicidin vs Protegrin

Indolicidin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Indolicidin
Antimicrobial Peptide

Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil granules. It is the smallest naturally occurring AMP with broad-spectrum activity....

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Indolicidin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Phase II (completed) Phase III (failed)
Half-Life Minutes to hours Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Topical Topical / Rinse
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Indolicidin and Protegrin?
Indolicidin: Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil granules. It is the smallest naturally occurring AMP with broad-spectrum activity.... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Indolicidin or Protegrin?
Indolicidin half-life: Minutes to hours. Protegrin half-life: Hours (disulfide stabilized).
Can you stack Indolicidin and Protegrin?
Indolicidin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.