Side-by-Side Comparison · 2026

Intermedin vs Relaxin-2

Intermedin vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Intermedin
Cardiovascular Peptide

Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widely expressed in the heart, lung, kidney, gut, and brain....

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Intermedin Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical Research Clinical
Half-Life ~15-30 minutes 10-15 min (plasma)
Typical Dose 1-100 pmol/kg/min infusion (animal) 30-300 mcg/kg/day (IV)
Frequency Acute infusion Continuous 48-hour infusion (trials)
Route IV (research); SC in some studies Intravenous (infusion)
FDA Status Research compound Not approved (Phase III completed)

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Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

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Frequently Asked Questions
What is the difference between Intermedin and Relaxin-2?
Intermedin: Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widel... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Intermedin or Relaxin-2?
Intermedin half-life: ~15-30 minutes. Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Intermedin and Relaxin-2?
Intermedin and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.