Side-by-Side Comparison · 2026

Intermedin vs Urocortin

Intermedin vs Urocortin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Intermedin
Cardiovascular Peptide

Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widely expressed in the heart, lung, kidney, gut, and brain....

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Urocortin
Cardiovascular Peptide

Urocortin 1 (UCN1) is a 40-amino acid peptide belonging to the corticotropin-releasing factor (CRF) family. While sharing structural homology with CRF, UCN1 binds with higher affinity to CRF receptor type 2 (CRFR2), which predominates in the heart, skeletal muscle, and peripheral...

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Key Parameters
Parameter Intermedin Urocortin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical Research Clinical
Half-Life ~15-30 minutes 1-3 hours
Typical Dose 1-100 pmol/kg/min infusion (animal) 0.5-10 pmol/kg/min (IV infusion)
Frequency Acute infusion Acute infusion or short courses
Route IV (research); SC in some studies Intravenous, Subcutaneous
FDA Status Research compound Not approved

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Frequently Asked Questions
What is the difference between Intermedin and Urocortin?
Intermedin: Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widel... Urocortin: Urocortin 1 (UCN1) is a 40-amino acid peptide belonging to the corticotropin-releasing factor (CRF) family. While sharing structural homology with CRF, UCN1 binds with higher affinity to CRF receptor ...
Which has a longer half-life, Intermedin or Urocortin?
Intermedin half-life: ~15-30 minutes. Urocortin half-life: 1-3 hours.
Can you stack Intermedin and Urocortin?
Intermedin and Urocortin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.