Side-by-Side Comparison · 2026

Kalata B1 vs Nisin

Kalata B1 vs Nisin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Kalata B1
Antimicrobial Peptide

Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis, which is traditionally used in Africa to accelerate childbirth (uterotonic use)...

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Nisin
Antimicrobial Peptide

Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food preservative in dairy, canned goods, and processed meats....

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Key Parameters
Parameter Kalata B1 Nisin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical GRAS Food Use / Preclinical (medical)
Half-Life Hours (resistant to all proteases) Minutes-hours (pH and protease dependent)
Typical Dose N/A N/A (food use to ~500 ppm)
Frequency N/A N/A
Route Research only (oral stability under study) Topical / Oral (food use)
FDA Status Not approved GRAS (food) / Investigational (medical)

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Frequently Asked Questions
What is the difference between Kalata B1 and Nisin?
Kalata B1: Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis,... Nisin: Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is the only bacteriocin approved for food use by the FDA (GRAS status, E234 in EU), widely used as a natural food p...
Which has a longer half-life, Kalata B1 or Nisin?
Kalata B1 half-life: Hours (resistant to all proteases). Nisin half-life: Minutes-hours (pH and protease dependent).
Can you stack Kalata B1 and Nisin?
Kalata B1 and Nisin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.