Side-by-Side Comparison · 2026

Kalata B1 vs Omiganan

Kalata B1 vs Omiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Kalata B1
Antimicrobial Peptide

Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis, which is traditionally used in Africa to accelerate childbirth (uterotonic use)...

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Omiganan
Antimicrobial Peptide

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection prevention, and rosacea....

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Key Parameters
Parameter Kalata B1 Omiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase 3 (Completed)
Half-Life Hours (resistant to all proteases) Hours (topical)
Typical Dose N/A 1-3% gel
Frequency N/A Twice daily
Route Research only (oral stability under study) Topical gel/cream
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Kalata B1 and Omiganan?
Kalata B1: Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis,... Omiganan: Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. It was developed for topical antimicrobial applications including acne vulgaris, catheter-site infection preve...
Which has a longer half-life, Kalata B1 or Omiganan?
Kalata B1 half-life: Hours (resistant to all proteases). Omiganan half-life: Hours (topical).
Can you stack Kalata B1 and Omiganan?
Kalata B1 and Omiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.