Side-by-Side Comparison · 2026

Kalata B1 vs Pexiganan

Kalata B1 vs Pexiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Kalata B1
Antimicrobial Peptide

Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis, which is traditionally used in Africa to accelerate childbirth (uterotonic use)...

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Pexiganan
Antimicrobial Peptide

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later Genaera) as a topical treatment for mildly infected diabetic foot ulcers....

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Key Parameters
Parameter Kalata B1 Pexiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase 3 (Failed 1999)
Half-Life Hours (resistant to all proteases) Hours (topical)
Typical Dose N/A 0.8% cream topically
Frequency N/A Twice daily
Route Research only (oral stability under study) Topical cream
FDA Status Not approved Not approved (failed Phase 3)

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Frequently Asked Questions
What is the difference between Kalata B1 and Pexiganan?
Kalata B1: Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis,... Pexiganan: Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later...
Which has a longer half-life, Kalata B1 or Pexiganan?
Kalata B1 half-life: Hours (resistant to all proteases). Pexiganan half-life: Hours (topical).
Can you stack Kalata B1 and Pexiganan?
Kalata B1 and Pexiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.