Side-by-Side Comparison · 2026

Kalata B1 vs PGLa

Kalata B1 vs PGLa — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Kalata B1
Antimicrobial Peptide

Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis, which is traditionally used in Africa to accelerate childbirth (uterotonic use)...

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PGLa
Antimicrobial Peptide

PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobial activity, but when combined at equimolar ratios, they exhibit synergistic kill...

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Key Parameters
Parameter Kalata B1 PGLa
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Hours (resistant to all proteases) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only (oral stability under study) Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Kalata B1 and PGLa?
Kalata B1: Kalata B1 is the prototype cyclotide - a cyclic peptide with a head-to-tail backbone cyclization and three disulfide bonds forming a cystine knot topology. Isolated from the plant Oldenlandia affinis,... PGLa: PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobia...
Which has a longer half-life, Kalata B1 or PGLa?
Kalata B1 half-life: Hours (resistant to all proteases). PGLa half-life: Minutes (proteolytic).
Can you stack Kalata B1 and PGLa?
Kalata B1 and PGLa are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.