Side-by-Side Comparison · 2026

Lactoferricin vs Pexiganan

Lactoferricin vs Pexiganan — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Lactoferricin
Antimicrobial Peptide

Lactoferricin B (LfcinB) is a 25-residue antimicrobial peptide released from the N-terminal region of bovine lactoferrin by pepsin digestion in the stomach. The core hexapeptide RRWQWR contains the minimal active unit....

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Pexiganan
Antimicrobial Peptide

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later Genaera) as a topical treatment for mildly infected diabetic foot ulcers....

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Key Parameters
Parameter Lactoferricin Pexiganan
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase 3 (Failed 1999)
Half-Life Minutes (proteolytic) Hours (topical)
Typical Dose N/A 0.8% cream topically
Frequency N/A Twice daily
Route Research only Topical cream
FDA Status Not approved Not approved (failed Phase 3)

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Frequently Asked Questions
What is the difference between Lactoferricin and Pexiganan?
Lactoferricin: Lactoferricin B (LfcinB) is a 25-residue antimicrobial peptide released from the N-terminal region of bovine lactoferrin by pepsin digestion in the stomach. The core hexapeptide RRWQWR contains the mi... Pexiganan: Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spectrum antimicrobial activity and reduced hemolytic toxicity. It was developed by Magainin Pharmaceuticals (later...
Which has a longer half-life, Lactoferricin or Pexiganan?
Lactoferricin half-life: Minutes (proteolytic). Pexiganan half-life: Hours (topical).
Can you stack Lactoferricin and Pexiganan?
Lactoferricin and Pexiganan are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.